ctcRbase

Entry Detail

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General Information

Database ID: BRCA08298 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: HMGCR Full Name: 3-hydroxy-3-methylglutaryl-CoA reductase Category: mRNA Synonyms: LDLCQ3 Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 75336329 End Site(bp): 75362104 Gene Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] External Links: Ensembl ID: ENSG00000113161 HGNC ID: HGNC:5006 Entrez Gene: 3156

Expression Profile of HMGCR Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-139-5p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-149-5p YES YES YES hsa-miR-155-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-206 YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-21-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-224-5p YES NO YES hsa-miR-25-3p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-32-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-361-5p YES NO YES hsa-miR-363-3p YES YES NO hsa-miR-365a-3p YES NO YES hsa-miR-367-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-431-5p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-496 YES YES NO hsa-miR-543 YES YES NO hsa-miR-582-5p YES NO YES hsa-miR-590-5p YES YES NO hsa-miR-613 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-760 YES NO YES hsa-miR-873-5p YES NO YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: