ctcRbase

Entry Detail

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General Information

Database ID: BRCA11194 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: NF2 Full Name: neurofibromin 2 Category: mRNA Synonyms: ACN|BANF|SCH Chromosome: chr22 Strand: + Coordinate: Start Site(bp): 29603556 End Site(bp): 29698598 Gene Summary: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000186575 HGNC ID: HGNC:7773 Entrez Gene: 4771

Expression Profile of NF2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-146a-5p YES YES YES hsa-miR-146b-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-326 YES YES NO hsa-miR-328-3p YES NO YES hsa-miR-330-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-376c-3p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: