ctcRbase

Entry Detail

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General Information

Database ID: BRCA23830 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: DLAT Full Name: dihydrolipoamide S-acetyltransferase Category: mRNA Synonyms: DLTA|PDC-E2|PDCE2 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 112024814 End Site(bp): 112064390 Gene Summary: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009] External Links: Ensembl ID: ENSG00000150768 HGNC ID: HGNC:2896 Entrez Gene: 1737

Expression Profile of DLAT Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p NO YES YES hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-365a-3p YES YES YES hsa-miR-378a-3p YES YES NO hsa-miR-384 YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-487b-3p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-96-5p YES YES YES Display: