ctcRbase

Entry Detail

---



General Information

Database ID: BRCA24167 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PAM Full Name: peptidylglycine alpha-amidating monooxygenase Category: mRNA Synonyms: PAL|PHM Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 102753981 End Site(bp): 103031105 Gene Summary: This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] External Links: Ensembl ID: ENSG00000145730 HGNC ID: HGNC:8596 Entrez Gene: 5066

Expression Profile of PAM Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-184 YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-212-3p YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-32-5p YES YES NO hsa-miR-329-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES YES hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-409-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-499a-5p YES YES NO hsa-miR-503-5p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-93-5p YES YES NO Display: