ctcRbase

Entry Detail

---



General Information

Database ID: BRCA25377 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CIC Full Name: capicua transcriptional repressor Category: mRNA Synonyms: MRD45 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 42268537 End Site(bp): 42295797 Gene Summary: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] External Links: Ensembl ID: ENSG00000079432 HGNC ID: HGNC:14214 Entrez Gene: 23152

Expression Profile of CIC Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-137 YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-153-3p YES NO YES hsa-miR-154-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-326 YES YES YES hsa-miR-330-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-448 YES YES YES hsa-miR-490-3p YES NO YES hsa-miR-493-3p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES YES Display: