| ncRNA Symbol: | NFKB2 |
| Full Name: | nuclear factor kappa B subunit 2 |
| Category: | mRNA |
| Synonyms: | CVID10|H2TF1|LYT-10|LYT10|NF-kB2|p100|p49/p100|p52 |
| Chromosome: | chr10 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 102394110 | End Site(bp): | 102402529 |
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| Gene Summary: | This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
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