ctcRbase

Entry Detail

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General Information

Database ID: BRCA26238 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PTPRM Full Name: protein tyrosine phosphatase, receptor type M Category: mRNA Synonyms: PTPRL1|R-PTP-MU|RPTPM|RPTPU|hR-PTPu Chromosome: chr18 Strand: + Coordinate: Start Site(bp): 7566782 End Site(bp): 8406861 Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000173482 HGNC ID: HGNC:9675 Entrez Gene: 5797

Expression Profile of PTPRM Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-147a YES NO NO hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-205-5p YES YES YES hsa-miR-211-5p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-330-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-375 YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES Display: