ctcRbase

Entry Detail

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General Information

Database ID: BRCA26486 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PPM1D Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1D Category: mRNA Synonyms: IDDGIP|PP2C-DELTA|WIP1 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 60600183 End Site(bp): 60666280 Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000170836 HGNC ID: HGNC:9277 Entrez Gene: 8493

Expression Profile of PPM1D Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-129-2-3p YES NO YES hsa-miR-145-5p YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-208a-3p YES YES YES hsa-miR-208b-3p YES YES YES hsa-miR-217 YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-24-3p YES NO YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-346 YES YES NO hsa-miR-361-5p YES YES YES hsa-miR-365a-3p YES YES YES hsa-miR-381-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-409-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES NO hsa-miR-448 YES YES NO hsa-miR-494-3p YES NO YES hsa-miR-497-5p YES YES YES hsa-miR-499a-5p YES YES YES hsa-miR-503-5p YES YES YES hsa-miR-543 YES YES NO hsa-miR-599 YES YES NO Display: