ctcRbase

Entry Detail

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General Information

Database ID: BRCA26579 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: SHANK3 Full Name: SH3 and multiple ankyrin repeat domains 3 Category: mRNA Synonyms: DEL22q13.3|PROSAP2|PSAP2|SCZD15|SPANK-2 Chromosome: chr22 Strand: + Coordinate: Start Site(bp): 50674415 End Site(bp): 50733298 Gene Summary: This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000251322 HGNC ID: HGNC:14294 Entrez Gene: 85358

Expression Profile of SHANK3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES YES hsa-miR-10b-5p YES YES YES hsa-miR-134-5p YES YES NO hsa-miR-191-5p YES YES YES hsa-miR-34a-5p YES NO YES hsa-miR-34c-5p YES NO YES hsa-miR-376c-3p YES YES YES hsa-miR-378a-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-449a YES NO YES hsa-miR-449b-5p YES NO YES hsa-miR-491-5p YES NO YES hsa-miR-494-3p YES YES YES hsa-miR-663a YES NO NO Display: