ctcRbase

Entry Detail

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General Information

Database ID: BRCA26808 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: SESN1 Full Name: sestrin 1 Category: mRNA Synonyms: PA26|SEST1 Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 108986437 End Site(bp): 109094819 Gene Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] External Links: Ensembl ID: ENSG00000080546 HGNC ID: HGNC:21595 Entrez Gene: 27244

Expression Profile of SESN1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-132-3p YES YES NO hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-140-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-24-3p YES YES YES hsa-miR-28-5p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-590-5p YES YES YES hsa-miR-655-3p YES NO YES hsa-miR-708-5p YES YES NO hsa-miR-876-5p YES YES NO Display: