ctcRbase

Entry Detail

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General Information

Database ID: BRCA26830 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: SHANK2 Full Name: SH3 and multiple ankyrin repeat domains 2 Category: mRNA Synonyms: AUTS17|CORTBP1|CTTNBP1|ProSAP1|SHANK|SPANK-3 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 70467856 End Site(bp): 71252577 Gene Summary: This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] External Links: Ensembl ID: ENSG00000162105 HGNC ID: HGNC:14295 Entrez Gene: 22941

Expression Profile of SHANK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-124-3p YES NO YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-147a YES NO NO hsa-miR-17-5p YES YES YES hsa-miR-186-5p YES NO YES hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-218-5p YES YES YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-28-5p YES YES YES hsa-miR-300 YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-411-5p YES NO YES hsa-miR-421 YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-490-3p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES NO YES hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-582-5p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-708-5p YES YES YES hsa-miR-93-5p YES YES YES Display: