ctcRbase

Entry Detail

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General Information

Database ID: BRCA26853 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: MVB12B Full Name: multivesicular body subunit 12B Category: mRNA Synonyms: C9orf28|FAM125B Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 126326849 End Site(bp): 126507041 Gene Summary: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000196814 HGNC ID: HGNC:23368 Entrez Gene: 89853

Expression Profile of MVB12B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-128-3p YES YES YES hsa-miR-129-2-3p YES NO YES hsa-miR-140-3p YES NO YES hsa-miR-141-3p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-218-5p YES NO YES hsa-miR-22-3p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-377-3p YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-98-5p YES NO YES Display: