ctcRbase

Entry Detail

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General Information

Database ID: BRCA27715 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: MAP3K5 Full Name: mitogen-activated protein kinase kinase kinase 5 Category: mRNA Synonyms: ASK1|MAPKKK5|MEKK5 Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 136557047 End Site(bp): 136792518 Gene Summary: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000197442 HGNC ID: HGNC:6857 Entrez Gene: 4217

Expression Profile of MAP3K5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES NO YES hsa-miR-17-5p YES YES YES hsa-miR-199a-3p YES NO YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-3p YES NO YES hsa-miR-199b-5p YES YES YES hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-296-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-425-5p YES YES YES hsa-miR-429 YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-93-5p YES YES YES Display: