ctcRbase

Entry Detail

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General Information

Database ID: BRCA28326 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MAFK Full Name: MAF bZIP transcription factor K Category: mRNA Synonyms: NFE2U|P18 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 1530714 End Site(bp): 1543043 Gene Summary: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] External Links: Ensembl ID: ENSG00000198517 HGNC ID: HGNC:6782 Entrez Gene: 7975

Expression Profile of MAFK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-137 YES NO YES hsa-miR-144-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-25-3p YES NO YES hsa-miR-32-5p YES NO YES hsa-miR-363-3p YES NO YES hsa-miR-367-3p YES NO YES hsa-miR-424-5p YES YES YES hsa-miR-433-3p YES YES NO hsa-miR-495-3p YES NO YES hsa-miR-497-5p YES YES YES hsa-miR-582-5p YES NO YES hsa-miR-92a-3p YES NO YES hsa-miR-92b-3p YES NO YES Display: