ctcRbase

Entry Detail

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General Information

Database ID: BRCA28983 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: LFNG Full Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Category: mRNA Synonyms: SCDO3 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 2512529 End Site(bp): 2529177 Gene Summary: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. [provided by RefSeq, May 2018] External Links: Ensembl ID: ENSG00000106003 HGNC ID: HGNC:6560 Entrez Gene: 3955

Expression Profile of LFNG Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-146a-5p YES YES YES hsa-miR-146b-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-362-3p YES NO NO hsa-miR-384 YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-7-5p YES YES NO Display: