ctcRbase

Entry Detail

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General Information

Database ID: BRCA28986 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: ABAT Full Name: 4-aminobutyrate aminotransferase Category: mRNA Synonyms: GABA-AT|GABAT|NPD009 Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 8674565 End Site(bp): 8784575 Gene Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000183044 HGNC ID: HGNC:23 Entrez Gene: 18

Expression Profile of ABAT Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-149-5p YES YES NO hsa-miR-153-3p YES NO YES hsa-miR-155-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-219a-2-3p YES NO YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-409-5p YES NO YES hsa-miR-421 YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-448 YES YES YES hsa-miR-499a-5p YES YES YES hsa-miR-505-3p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-873-5p YES YES YES hsa-miR-874-3p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-9-5p YES NO YES hsa-miR-96-5p YES YES YES Display: