ctcRbase

Entry Detail

---



General Information

Database ID: BRCA29619 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: IL21R Full Name: interleukin 21 receptor Category: mRNA Synonyms: CD360|IMD56|NILR Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 27402162 End Site(bp): 27452042 Gene Summary: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] External Links: Ensembl ID: ENSG00000103522 HGNC ID: HGNC:6006 Entrez Gene: 50615

Expression Profile of IL21R Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-149-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-362-3p YES NO NO hsa-miR-421 YES YES YES hsa-miR-491-5p YES YES NO hsa-miR-874-3p YES YES NO Display: