ctcRbase

Entry Detail

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General Information

Database ID: BRCA30381 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: MLLT11 Full Name: MLLT11, transcription factor 7 cofactor Category: mRNA Synonyms: AF1Q Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 151057758 End Site(bp): 151068497 Gene Summary: The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000213190 HGNC ID: HGNC:16997 Entrez Gene: 10962

Expression Profile of MLLT11 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-186-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-874-3p YES YES NO hsa-miR-875-5p YES YES NO Display: