ctcRbase

Entry Detail

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General Information

Database ID: BRCA30528 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: GPT2 Full Name: glutamic--pyruvic transaminase 2 Category: mRNA Synonyms: ALT2|GPT 2|MRT49 Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 46884378 End Site(bp): 46931297 Gene Summary: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] External Links: Ensembl ID: ENSG00000166123 HGNC ID: HGNC:18062 Entrez Gene: 84706

Expression Profile of GPT2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES NO YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-374a-5p YES NO YES hsa-miR-374b-5p YES NO YES hsa-miR-377-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES YES hsa-miR-876-5p YES YES NO Display: