ctcRbase

Entry Detail

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General Information

Database ID: BRCA31820 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: TNK2 Full Name: tyrosine kinase non receptor 2 Category: mRNA Synonyms: ACK|ACK-1|ACK1|p21cdc42Hs Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 195863364 End Site(bp): 195911945 Gene Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000061938 HGNC ID: HGNC:19297 Entrez Gene: 10188

Expression Profile of TNK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-138-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-184 YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-326 YES YES YES hsa-miR-330-5p YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-7-5p YES NO YES Display: