ctcRbase

Entry Detail

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General Information

Database ID: BRCA32925 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: BMP2 Full Name: bone morphogenetic protein 2 Category: mRNA Synonyms: BDA2|BMP2A|SSFSC Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 6767664 End Site(bp): 6780280 Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] External Links: Ensembl ID: ENSG00000125845 HGNC ID: HGNC:1069 Entrez Gene: 650

Expression Profile of BMP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-129-5p YES NO YES hsa-miR-140-5p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-370-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-384 YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-488-3p YES YES YES hsa-miR-505-3p YES NO YES hsa-miR-519d-3p YES YES NO hsa-miR-543 YES YES YES hsa-miR-93-5p YES YES NO hsa-miR-98-5p YES YES YES Display: