ctcRbase

Entry Detail

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General Information

Database ID: BRCA33888 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: MASP1 Full Name: mannan binding lectin serine peptidase 1 Category: mRNA Synonyms: 3MC1|CRARF|CRARF1|MAP1|MASP|MASP3|MAp44|PRSS5|RaRF Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 187217285 End Site(bp): 187292022 Gene Summary: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] External Links: Ensembl ID: ENSG00000127241 HGNC ID: HGNC:6901 Entrez Gene: 5648

Expression Profile of MASP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-122-5p YES YES YES hsa-miR-1271-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-185-5p YES NO NO hsa-miR-195-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-300 YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-96-5p YES YES NO hsa-miR-98-5p YES YES YES Display: