ctcRbase

Entry Detail

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General Information

Database ID: BRCA33924 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: NOTCH1 Full Name: notch 1 Category: mRNA Synonyms: AOS5|AOVD1|TAN1|hN1 Chromosome: chr9 Strand: - Coordinate: Start Site(bp): 136494444 End Site(bp): 136545862 Gene Summary: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016] External Links: Ensembl ID: ENSG00000148400 HGNC ID: HGNC:7881 Entrez Gene: 4851

Expression Profile of NOTCH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-137 YES YES YES hsa-miR-139-5p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-433-3p YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-582-5p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: