ctcRbase

Entry Detail

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General Information

Database ID: BRCA34049 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: GDF6 Full Name: growth differentiation factor 6 Category: mRNA Synonyms: BMP-13|BMP13|CDMP2|KFM|KFS|KFS1|KFSL|SGM1|SYNS4 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 96142330 End Site(bp): 96160792 Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis. [provided by RefSeq, Sep 2016] External Links: Ensembl ID: ENSG00000156466 HGNC ID: HGNC:4221 Entrez Gene: 392255

Expression Profile of GDF6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-128-3p YES NO YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-324-5p YES YES YES hsa-miR-330-3p YES NO YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-379-5p YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-448 YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES YES hsa-miR-98-5p YES YES YES Display: