ctcRbase

Entry Detail

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General Information

Database ID: BRCA35240 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: UPF1 Full Name: UPF1, RNA helicase and ATPase Category: mRNA Synonyms: HUPF1|NORF1|RENT1|pNORF1|smg-2 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 18831938 End Site(bp): 18868236 Gene Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] External Links: Ensembl ID: ENSG00000005007 HGNC ID: HGNC:9962 Entrez Gene: 5976

Expression Profile of UPF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES YES hsa-miR-150-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-370-3p YES NO YES hsa-miR-377-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-532-3p YES NO YES hsa-miR-542-3p YES YES NO Display: