ctcRbase

Entry Detail

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General Information

Database ID: BRCA35961 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PIK3C2B Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Category: mRNA Synonyms: C2-PI3K Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 204422628 End Site(bp): 204494724 Gene Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000133056 HGNC ID: HGNC:8972 Entrez Gene: 5287

Expression Profile of PIK3C2B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-1197 YES NO YES hsa-miR-145-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-188-5p YES NO YES hsa-miR-197-3p YES YES NO hsa-miR-204-5p YES NO YES hsa-miR-211-5p YES NO YES hsa-miR-296-5p YES NO YES hsa-miR-300 YES YES YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-802 YES NO YES hsa-miR-874-3p YES YES NO Display: