ctcRbase

Entry Detail

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General Information

Database ID: BRCA36817 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: LRP1 Full Name: LDL receptor related protein 1 Category: mRNA Synonyms: A2MR|APOER|APR|CD91|IGFBP-3R|IGFBP3R|IGFBP3R1|KPA|LRP|LRP1A|TGFBR5 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 57128493 End Site(bp): 57213351 Gene Summary: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000123384 HGNC ID: HGNC:6692 Entrez Gene: 4035

Expression Profile of LRP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO YES hsa-miR-106a-5p YES YES NO hsa-miR-107 YES NO YES hsa-miR-17-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-205-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-429 YES YES YES Display: