ctcRbase

Entry Detail

---



General Information

Database ID: BRCA37209 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: TRAF3 Full Name: TNF receptor associated factor 3 Category: mRNA Synonyms: CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118 Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 102777476 End Site(bp): 102911500 Gene Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010] External Links: Ensembl ID: ENSG00000131323 HGNC ID: HGNC:12033 Entrez Gene: 7187

Expression Profile of TRAF3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-147a YES NO NO hsa-miR-186-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-28-3p YES NO YES hsa-miR-32-5p YES YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-361-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-494-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: