| ncRNA Symbol: | TLE6 | | Full Name: | TLE family member 6, subcortical maternal complex member | | Category: | mRNA | | Synonyms: | GRG6|PREMBL | | Chromosome: | chr19 | | Strand: | + | | Coordinate: | | Start Site(bp): | 2977446 | End Site(bp): | 2995184 |
| | Gene Summary: | This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] | | External Links: | |
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