ctcRbase

Entry Detail

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General Information

Database ID: BRCA37619 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: MSH3 Full Name: mutS homolog 3 Category: mRNA Synonyms: DUP|FAP4|MRP1 Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 80654648 End Site(bp): 80876460 Gene Summary: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011] External Links: Ensembl ID: ENSG00000113318 HGNC ID: HGNC:7326 Entrez Gene: 4437

Expression Profile of MSH3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-375 YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-93-5p YES YES NO Display: