ctcRbase

Entry Detail

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General Information

Database ID: BRCA37860 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CDKN2B Full Name: cyclin dependent kinase inhibitor 2B Category: mRNA Synonyms: CDK4I|INK4B|MTS2|P15|TP15|p15INK4b Chromosome: chr9 Strand: - Coordinate: Start Site(bp): 22002903 End Site(bp): 22009363 Gene Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000147883 HGNC ID: HGNC:1788 Entrez Gene: 1030

Expression Profile of CDKN2B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-147a YES NO NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-195-5p YES NO YES hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-424-5p YES NO YES hsa-miR-451a YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-541-3p YES NO NO hsa-miR-582-5p YES NO YES hsa-miR-654-5p YES NO NO hsa-miR-665 YES NO YES hsa-miR-708-5p YES YES NO Display: