ctcRbase

Entry Detail

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General Information

Database ID: BRCA37909 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: SIRPA Full Name: signal regulatory protein alpha Category: mRNA Synonyms: BIT|CD172A|MFR|MYD-1|P84|PTPNS1|SHPS1|SIRP Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 1894167 End Site(bp): 1940592 Gene Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000198053 HGNC ID: HGNC:9662 Entrez Gene: 140885

Expression Profile of SIRPA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-1323 YES NO NO hsa-miR-140-3p YES NO YES hsa-miR-145-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-184 YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-24-3p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-300 YES YES YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-324-5p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-326 YES YES YES hsa-miR-330-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-381-3p YES YES YES hsa-miR-382-5p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-548o-3p YES NO NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES YES Display: