ctcRbase

Entry Detail

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General Information

Database ID: BRCA38180 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: ACVR2A Full Name: activin A receptor type 2A Category: mRNA Synonyms: ACTRII|ACVR2 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 147844517 End Site(bp): 147930826 Gene Summary: This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013] External Links: Ensembl ID: ENSG00000121989 HGNC ID: HGNC:173 Entrez Gene: 92

Expression Profile of ACVR2A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-103a-3p YES NO NO hsa-miR-107 YES NO NO hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-138-5p YES NO YES hsa-miR-139-5p YES YES NO hsa-miR-141-3p YES YES YES hsa-miR-142-3p YES YES YES hsa-miR-145-5p YES NO YES hsa-miR-155-5p YES YES YES hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES NO YES hsa-miR-199a-3p YES NO YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-3p YES NO YES hsa-miR-199b-5p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-21-5p YES NO YES hsa-miR-217 YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-223-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-409-5p YES NO YES hsa-miR-424-5p YES NO YES hsa-miR-448 YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-503-5p YES NO NO hsa-miR-506-3p YES NO YES hsa-miR-543 YES YES NO hsa-miR-590-5p YES NO YES hsa-miR-96-5p YES YES YES hsa-miR-98-5p YES NO YES Display: