ctcRbase

Entry Detail

---



General Information

Database ID: BRCA38683 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: TNK1 Full Name: tyrosine kinase non receptor 1 Category: mRNA Synonyms: - Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 7380534 End Site(bp): 7389774 Gene Summary: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] External Links: Ensembl ID: ENSG00000174292 HGNC ID: HGNC:11940 Entrez Gene: 8711

Expression Profile of TNK1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-488-3p YES YES NO Display: