ctcRbase

Entry Detail

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General Information

Database ID: BRCA38783 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: MMP2 Full Name: matrix metallopeptidase 2 Category: mRNA Synonyms: CLG4|CLG4A|MMP-2|MMP-II|MONA|TBE-1 Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 55389700 End Site(bp): 55506691 Gene Summary: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] External Links: Ensembl ID: ENSG00000087245 HGNC ID: HGNC:7166 Entrez Gene: 4313

Expression Profile of MMP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-130b-3p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-328-3p YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-506-3p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-93-5p YES YES YES Display: