ctcRbase

Entry Detail

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General Information

Database ID: BRCA40602 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CTIF Full Name: cap binding complex dependent translation initiation factor Category: mRNA Synonyms: Gm672|KIAA0427 Chromosome: chr18 Strand: + Coordinate: Start Site(bp): 48539046 End Site(bp): 48863217 Gene Summary: CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009] External Links: Ensembl ID: ENSG00000134030 HGNC ID: HGNC:23925 Entrez Gene: 9811

Expression Profile of CTIF Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-138-5p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-193a-3p YES NO YES hsa-miR-193b-3p YES NO YES hsa-miR-195-5p YES YES YES hsa-miR-221-3p YES NO YES hsa-miR-222-3p YES NO YES hsa-miR-299-5p YES NO YES hsa-miR-31-5p YES NO YES hsa-miR-370-3p YES NO YES hsa-miR-424-5p YES YES YES hsa-miR-491-5p YES NO YES hsa-miR-497-5p YES YES YES hsa-miR-551a YES NO YES hsa-miR-551b-3p YES NO YES Display: