ctcRbase

Entry Detail

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General Information

Database ID: BRCA41875 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: ERBB4 Full Name: erb-b2 receptor tyrosine kinase 4 Category: mRNA Synonyms: ALS19|HER4|p180erbB4 Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 211375717 End Site(bp): 212538841 Gene Summary: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000178568 HGNC ID: HGNC:3432 Entrez Gene: 2066

Expression Profile of ERBB4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES NO YES hsa-miR-1297 YES NO YES hsa-miR-135a-5p YES NO YES hsa-miR-135b-5p YES NO YES hsa-miR-145-5p YES YES NO hsa-miR-186-5p YES NO NO hsa-miR-193a-3p YES NO YES hsa-miR-193b-3p YES NO YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-22-3p YES NO YES hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-300 YES NO YES hsa-miR-330-3p YES NO YES hsa-miR-339-5p YES NO YES hsa-miR-381-3p YES NO YES hsa-miR-383-5p YES NO YES hsa-miR-433-3p YES NO YES hsa-miR-455-5p YES NO YES hsa-miR-483-3p YES NO YES hsa-miR-551a YES YES YES hsa-miR-551b-3p YES YES YES hsa-miR-625-5p YES NO NO hsa-miR-7-5p YES NO YES Display: