ctcRbase

Entry Detail

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General Information

Database ID: BRCA42268 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: BACE1 Full Name: beta-secretase 1 Category: mRNA Synonyms: ASP2|BACE|HSPC104 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 117285207 End Site(bp): 117316259 Gene Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015] External Links: Ensembl ID: ENSG00000186318 HGNC ID: HGNC:933 Entrez Gene: 23621

Expression Profile of BACE1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES NO YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-141-3p YES NO YES hsa-miR-155-5p YES YES NO hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-195-5p YES NO YES hsa-miR-200a-3p YES NO YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-299-5p YES NO YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-424-5p YES NO YES hsa-miR-454-3p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-499a-5p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-655-3p YES NO YES hsa-miR-7-5p YES YES YES Display: