ctcRbase

Entry Detail

---



General Information

Database ID: BRCA42592 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: CLCF1 Full Name: cardiotrophin like cytokine factor 1 Category: mRNA Synonyms: BSF-3|BSF3|CISS2|CLC|NNT-1|NNT1|NR6 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 67364168 End Site(bp): 67374177 Gene Summary: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009] External Links: Ensembl ID: ENSG00000175505 HGNC ID: HGNC:17412 Entrez Gene: 23529

Expression Profile of CLCF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-216a-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-300 YES YES NO hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-31-5p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-873-5p YES YES YES Display: