ctcRbase

Entry Detail

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General Information

Database ID: BRCA42889 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: WRN Full Name: Werner syndrome RecQ like helicase Category: mRNA Synonyms: RECQ3|RECQL2|RECQL3 Chromosome: chr8 Strand: + Coordinate: Start Site(bp): 31033801 End Site(bp): 31173769 Gene Summary: This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000165392 HGNC ID: HGNC:12791 Entrez Gene: 7486

Expression Profile of WRN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-874-3p YES YES NO Display: