ctcRbase

Entry Detail

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General Information

Database ID: BRCA44228 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: RASGRP1 Full Name: RAS guanyl releasing protein 1 Category: mRNA Synonyms: CALDAG-GEFI|CALDAG-GEFII|RASGRP Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 38488103 End Site(bp): 38565575 Gene Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000172575 HGNC ID: HGNC:9878 Entrez Gene: 10125

Expression Profile of RASGRP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-196a-5p YES YES YES hsa-miR-196b-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-422a YES YES NO hsa-miR-429 YES YES NO hsa-miR-487a-3p YES NO YES hsa-miR-590-5p YES YES YES hsa-miR-875-5p YES YES NO hsa-miR-98-5p YES YES YES Display: