ctcRbase

Entry Detail

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General Information

Database ID: BRCA44444 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MMP14 Full Name: matrix metallopeptidase 14 Category: mRNA Synonyms: MMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRS Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 22836557 End Site(bp): 22849027 Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000157227 HGNC ID: HGNC:7160 Entrez Gene: 4323

Expression Profile of MMP14 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES NO YES hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-149-5p YES YES NO hsa-miR-150-5p YES NO YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-24-3p YES NO YES hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES NO YES hsa-miR-374b-5p YES NO YES hsa-miR-410-3p YES YES YES hsa-miR-485-5p YES YES YES hsa-miR-543 YES YES NO Display: