ctcRbase

Entry Detail

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General Information

Database ID: BRCA44813 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PEX5 Full Name: peroxisomal biogenesis factor 5 Category: mRNA Synonyms: PBD2A|PBD2B|PTS1-BP|PTS1R|PXR1|RCDP5 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 7188685 End Site(bp): 7218574 Gene Summary: The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] External Links: Ensembl ID: ENSG00000139197 HGNC ID: HGNC:9719 Entrez Gene: 5830

Expression Profile of PEX5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-126-3p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-143-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-183-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-216b-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-31-5p YES YES YES hsa-miR-32-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-384 YES YES NO hsa-miR-422a YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-582-5p YES NO YES hsa-miR-625-5p YES NO NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: