ctcRbase

Entry Detail

---



General Information

Database ID: BRCA44904 Cancer Type: breast cancer Dataset: GSE111842 CTCs/CTM Isolation Method: immunomagnetic FACS

Gene Information

ncRNA Symbol: SACS Full Name: sacsin molecular chaperone Category: mRNA Synonyms: ARSACS|DNAJC29|PPP1R138|SPAX6 Chromosome: chr13 Strand: - Coordinate: Start Site(bp): 23328826 End Site(bp): 23411513 Gene Summary: This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] External Links: Ensembl ID: ENSG00000151835 HGNC ID: HGNC:10519 Entrez Gene: 26278

Expression Profile of SACS Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-107 YES YES NO hsa-miR-129-2-3p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-145-5p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-384 YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-543 YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-93-5p YES YES YES hsa-miR-9-5p YES YES YES Display: