| Gene Summary: | The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense (GeneID: 11191) and antisense RNAs. This antisense RNA (asRNA) regulates PTEN transcription and mRNA stability. [provided by RefSeq, Apr 2013] |