| ncRNA Symbol: | NFE4 | | Full Name: | nuclear factor, erythroid 4 | | Category: | mRNA | | Synonyms: | NF-E4 | | Chromosome: | chr7 | | Strand: | + | | Coordinate: | | Start Site(bp): | 102973437 | End Site(bp): | 102988856 |
| | Gene Summary: | The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008] | | External Links: | |
|