ctcRbase

Entry Detail

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General Information

Database ID: BRCA46351 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: IL12A Full Name: interleukin 12A Category: mRNA Synonyms: CLMF|IL-12A|NFSK|NKSF1|P35 Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 159988750 End Site(bp): 159996019 Gene Summary: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000168811 HGNC ID: HGNC:5969 Entrez Gene: 3592

Expression Profile of IL12A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-590-5p YES YES YES hsa-miR-874-3p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-9-5p YES YES NO Display: