ctcRbase

Entry Detail

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General Information

Database ID: BRCA47750 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: CAVIN1 Full Name: caveolae associated protein 1 Category: mRNA Synonyms: CAVIN|CGL4|FKSG13|PTRF|cavin-1 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 42402452 End Site(bp): 42423517 Gene Summary: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009] External Links: Ensembl ID: ENSG00000177469 HGNC ID: HGNC:9688 Entrez Gene: 284119

Expression Profile of CAVIN1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1197 YES NO YES hsa-miR-185-5p YES YES NO hsa-miR-187-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-342-3p YES YES YES hsa-miR-370-3p YES YES YES hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-9-5p YES YES NO Display: