| ncRNA Symbol: | PRH1 |
| Full Name: | proline rich protein HaeIII subfamily 1 |
| Category: | mRNA |
| Synonyms: | Db-s|PA|PIF-S|PRH2|Pr1/Pr2 |
| Chromosome: | chr12 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 10824960 | End Site(bp): | 11171544 |
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| Gene Summary: | This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] |
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