| ncRNA Symbol: | PTPRN2 | | Full Name: | protein tyrosine phosphatase, receptor type N2 | | Category: | mRNA | | Synonyms: | IA-2beta|IAR|ICAAR|PTPRP|R-PTP-N2 | | Chromosome: | chr7 | | Strand: | - | | Coordinate: | | Start Site(bp): | 157539056 | End Site(bp): | 158587788 |
| | Gene Summary: | This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] | | External Links: | |
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